Q. A few weeks in the past, a lab take a look at revealed that my creatinine ranges are elevated. That is the primary time I’ve had any indication of kidney issues. I’m terrified.
I heard you focus on kidney injury associated to proton pump inhibitors. I’ve been taking omeprazole for greater than 20 years, and I worry this could be the reason for my excessive creatinine ranges.
A couple of years in the past, I attempted going off this treatment and had heartburn from the depths of hell. It really affected my high quality of life, so I resigned myself to taking it ceaselessly. What are you able to inform me about weaning off this drug?
A. Use of robust acid-suppressing medicine like omeprazole (Prilosec) has been linked to acute kidney harm and persistent kidney illness (Pharmacotherapy April 2019). Elevated creatinine ranges are a sign that the kidneys are underneath stress.
Getting off proton pump inhibitors (PPIs) will be very difficult, as you found. Rebound hyperacidity has been well-documented. You may need success with gradual tapering. Utilizing a histamine blocker akin to famotidine (Pepcid) may additionally ease the discomfort of your “heartburn from hell.”
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We focus on these and a number of other different approaches in additional element in our eGuide to Overcoming Digestive Issues. You will discover this on-line useful resource underneath the Well being eGuides tab at www. PeoplesPharmacy.com.
Q. I began having migraines a few many years in the past. They ramped up till they occurred greater than half the month.
I’ve tried ever so many remedies, together with hormones, dietary supplements, prophylactic and rescue medicines, train, acupuncture, therapeutic massage, Botox and meals sensitivity testing with main dietary modifications. What helped me probably the most was Ajovy. It took a while earlier than I realized tips on how to self-inject correctly, however since then, I’ve suffered a lot much less.
A. Migraine prevention and therapy has modified radically over the previous few years. There at the moment are a number of new medicine, together with fremanezumab (Ajovy), erenumab (Aimovig) and galcanezumab (Emgality). These are all self-injectable preventive medicines applicable for individuals who, such as you, have frequent migraines. Sadly, additionally they are all costly, starting from about $600 to $800 for a month-to-month shot.
Oral medicines that have an effect on the identical CGRP (calcitonin gene-related peptide) pathway have now turn out to be obtainable. Such medicine embrace atogepant (Qulipta), rimegepant (Nurtec) and ubrogepant (Ubrelvy). These are even pricier, at round $1,000 a month.
There are a number of different new migraine remedies as properly. Discovering the best match of therapy for every affected person will be difficult, so it is sensible to see a specialist. Getting insurance coverage corporations to pay is one other hurdle. Typically the physician’s workplace may also help.
Q. I learn someplace that very low ldl cholesterol from taking statins might trigger cataracts. I additionally noticed a remark that cataract surgical procedure was straightforward, so this was no drawback! What do you suppose?
A. Early-onset cataracts (in folks between 20 and 55 years of age) have been linked to statin use (Regulatory Toxicology and Pharmacology, August 2021). Different analysis additionally has discovered the next threat for cataracts amongst folks taking statins or another cholesterol-lowering medicine (Elementary & Medical Pharmacology, December 2019). The authors recommend that “… a decrease in cholesterol could be important in the pathophysiology of cataract in patients exposed to the main LLD [lipid-lowering drugs].”
Questions for Joe and Teresa Graedon will be emailed through their web site: www.PeoplesPharmacy.com.